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Rituximab structure. Some side effects may occur during the injection or within 24 hours afterward. To understand the molecular mechanism of recognition of human cd20 by rituximab we determined the crystal structure of the rituximab fab in complex with a synthesized peptide comprising the cd20 epitope residues 163 187 at 26 a resolution. Rituximab was developed by researcher nabil hanna and coworkers at idec pharmaceuticals under the name idec c2b8.
Dosage can vary depending on the desired treatment. The antibody is an igg1 kappa immunoglobulin containing murine light and heavy chain variable region sequences and human constant region sequences 6 label. The rcsb pdb also provides a variety of tools and resources.
Get emergency medical help if you have signs of an allergic reaction hives difficult breathing swelling in your face or throat or a severe skin reaction fever sore throat burning eyes skin pain red or purple skin rash with blistering and peeling. Patent for the drug was issued in 1998 and expired in 2015. Rituximab is a widely used monoclonal antibody drug for treating certain lymphomas and autoimmune diseases.
Bp35 which is found on mature b cells as well as 90 of b cell neoplasms such as non hodgkin lymphoma and chronic lymphocytic leukemia. Users can perform simple and advanced searches based on annotations relating to sequence structure and function. It is used in the treatment and care of patients with non hodgkins lymphoma chronic lymphocytic leukemia rheumatoid arthritis granulomatosis with polyangiitis and microscopic polyangiitis.
Binding regions from original murine anti human cd20 consisting of variable regions of immunoglobulin heavy and light chains are fused to human igg1 heavy chain and. As a member of the wwpdb the rcsb pdb curates and annotates pdb data according to agreed upon standards. Description rituximab is a genetically engineered chimeric murinehuman monoclonal antibody directed against the cd20 antigen found on the surface of normal and malignant b lymphocytes.
Rituximab is a liquid drug that is administered into patients veins. If you used rituximab intravenous when you were pregnant tell your babys doctor. These molecules are visualized downloaded and analyzed by users who range from students to specialized scientists.